Canvax Leukotriene B4 Receptor G0564-A

Leukotriene B4 Receptor, ExpressMAX™ Human GPCR ORF Clones

Leukotriene B4 Receptor is a G protein-coupled seven transmembrane domain receptors. Its gene is located in very close proximity to another leukotriene receptor, BLT2, both in the Human and mouse genomes. The two receptors differ in their affinity and specificity for LTB4 being LTB4R a high-affinity receptor specific for LTB4 and in their pattern of expression. LTB4R is expressed primarily in leukocytes. Reduced disease severity in animal inflammatory models seen with LTB4 receptor antagonists and in mice with targeted deletion of BLT1 have revealed important roles for LTB4 and its receptors in regulating pathologic inflammation.

Main Features:

Native structure. Wide range: a large collection of ExpressMAX™ GPCR ORF Clones availables. Highest levels of GPCR expression: on surface cell lines, > 50% of TAG detection by cytometry. Wide spectrum: of strong constitutive promoters. Complete solution: it contains all necessary elements for maximum receptor expression. Ready-to-use solution: avoids cloning steps, DNA ready to transfect. Easy protocol and detection: the whole procedure is simple, with minimal handling. Neomycin resistance. Ampicillin bacterial selection.

Includes: Includes for 15 µg: ExpressMAX™ GPCR ORF Clones (Cat. No. -A & B) - 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL) Mammalian Transfection Kits (Cat. No. -PLUS): - 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL) - 0.2 mL CANFAST™ Transfection Reagent (15 µg = 15 assays)

Applications: Functional assays, as protein immobilization, cellular localization and other functional assays. High-throughput and large scale protein production and purification. Reverse transfection arrays and nucleic acid programmable protein arrays (NAPPA).