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Canvax Cholinergic Receptor, Muscarinic 4 G0583-Plus
PART NO: CX-G0583-PLUS
Cholinergic Receptor, Muscarinic 4, ExpressMAX™ Human GPCR ORF Clones
Like other muscarinic receptors, the M4 receptor is widely expressed in different regions of the forebrain. Interestingly, M4receptor is coexpressed with D1 dopamine receptors in a specific subset of striatal projection neurons. Those receptors have opposing effects on the activity of adenylyl cyclase: activation of M4 receptor has an inhibitory effect on adenylyl cyclase whereas D1 has an increasement of intracellular cAMP levels.
Main Features:
Native structure. Wide range: A large collection of ExpressMAX™ GPCR ORF Clones availables. Highest levels of GPCR expression: on surface cell lines, > 50% of TAG detection by cytometry. Wide spectrum: of strong constitutive promoters. Complete solution: it contains all necessary elements for maximum receptor expression. Ready-to-use solution: avoids cloning steps, DNA ready to transfect. Easy protocol and detection: the whole procedure is simple, with minimal handling. Neomycin resistance. Ampicillin bacterial selection.
Includes: Includes for 15 µg: ExpressMAX™ GPCR ORF Clones (Cat. No. -A & B) - 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL) Mammalian Transfection Kits (Cat. No. -PLUS): - 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL) - 0.2 mL CANFAST™ Transfection Reagent (15 µg = 15 assays)
Applications: Functional assays, as protein immobilization, cellular localization and other functional assays. High-throughput and large scale protein production and purification. Reverse transfection arrays and nucleic acid programmable protein arrays (NAPPA).
Like other muscarinic receptors, the M4 receptor is widely expressed in different regions of the forebrain. Interestingly, M4receptor is coexpressed with D1 dopamine receptors in a specific subset of striatal projection neurons. Those receptors have opposing effects on the activity of adenylyl cyclase: activation of M4 receptor has an inhibitory effect on adenylyl cyclase whereas D1 has an increasement of intracellular cAMP levels.
Main Features:
Native structure. Wide range: A large collection of ExpressMAX™ GPCR ORF Clones availables. Highest levels of GPCR expression: on surface cell lines, > 50% of TAG detection by cytometry. Wide spectrum: of strong constitutive promoters. Complete solution: it contains all necessary elements for maximum receptor expression. Ready-to-use solution: avoids cloning steps, DNA ready to transfect. Easy protocol and detection: the whole procedure is simple, with minimal handling. Neomycin resistance. Ampicillin bacterial selection.
Includes: Includes for 15 µg: ExpressMAX™ GPCR ORF Clones (Cat. No. -A & B) - 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL) Mammalian Transfection Kits (Cat. No. -PLUS): - 15 µg ExpressMAX™ Mammalian Expression Vector (1 mg/mL) - 0.2 mL CANFAST™ Transfection Reagent (15 µg = 15 assays)
Applications: Functional assays, as protein immobilization, cellular localization and other functional assays. High-throughput and large scale protein production and purification. Reverse transfection arrays and nucleic acid programmable protein arrays (NAPPA).
| Format: 15 µL + 0.2 mL Shipping conditions: Dry Ice Storage Conditions: -20 ºC | |
| Manufacturer | Canvax |
| Manufacturer P/n | G0583 - Plus |