Canvax Human KAL1 Overexpression Lysate Product, Tag-free PR0511

Human KAL1 Overexpression Lysate Product, Tag-free, high quality recombinant protein with proven performance in elisa, wb, ab production or protein array

KAL1 (Anosmin 1) is a glycoprotein part of the extracellular matrix, which was first identified as defective in human Kallmann syndrome (KS, characterised by hypogonadotropic hypogonadism and anosmia), biochemically it is a cell adhesion protein. The meticulous biochemical dissection of the anosmin 1 domains has identified which domains are necessary for the protein to bind its different partners to display its biological effects. Research in the last decade has unravelled different roles of anosmin 1 during CNS development (axon pathfinding, axonal collateralisation, cell motility and migration), some of them intimately related with the cited KS but not only with this. More recently, anosmin 1 has been identified in other pathological scenarios both within (multiple sclerosis) and outside (cancer, atopic dermatitis) the CNS.

Main Features:

Highest purity: free of interferences from other proteins or contaminants. Convenient: available in different sizes and tags. Cost avoidance: dry ice free of charge.

Includes: Includes for 200 µg: - 200 µg Recombinant Protein - Dry ice

Applications: Western Blot: Product accompanied by 200 µg empty vector negative control. Prior SDS-PAGE fractionation, boil lysate 5 min.